What’s the best way to take CBD?
Lets learn a little about Human Cannabinoid Pharmacokinetics
If you want to get the most bioavailability out of your CBD, the most direct route would be intravenous administration, meaning injected directly into the bloodstream through the veins. While this method, by definition, delivers 100% of CBD into the body, it probably isn’t the most popular option. For anyone who doesn’t prefer to stick themselves with a needle, let’s talk about the different methods of using CBD, and how each affects CBD bioavailability.
Oral Consumption
Most of us know how oral consumption works. Basically it means to consume something through your mouth. In terms of CBD, common oral consumption methods include CBD capsules, CBD edibles and CBD beverages.
While oral consumption methods do offer certain benefits, any substance consumed will have to pass through our metabolic and digestive systems, which will filter out a large portion of the CBD, drastically reducing its bioavailability.
A 1986 study reported a bioavailability rate of 6%, while a 2009 study reported it between 4% and 20%. While both findings differ significantly, both are pretty low, with a 20% bioavailability rate being the most optimistic scenario.
To give you an idea on how that works, if you eat an edible that contains 100mg of CBD, only 20mg will actually reach your bloodstream.
Of course you need to accept that you’re going to lose a portion of the CBD to your digestive system, but over 75%? Wow!
Don’t worry though — there are other ways to increase your CBD bioavailability rate!
Topical
Another route of cannabinoid exposure that avoids first-pass metabolism and improves THC bioavailability is topical administration
Cannabinoids are highly hydrophobic, making transport across the aqueous layer of the skin the rate-limiting step in the diffusion process. In vitro diffusion studies may underestimate in vivo transdermal flux. After application of a dermal patch, mean steady-state plasma concentration of Δ8-THC was 4.4 ng/ml within 1.4 h, and was maintained for at least 48 h.
Permeabilities of CBD and CBN were found to be 10-fold higher than for Δ8-THC. In vivostudies of transdermal drug delivery in guinea pigs noted the presence of significant amounts of plasma metabolites after topical application of THC. Additional research is planned with combinations of cannabinoids in EtOH to increase drug absorption.
Transdermal delivery of cannabinoids is hoped to reduce negative side effects seen with inhalation dosing. Transdermal delivery also bypasses first-pass metabolism of cannabinoids. These properties could improve the utility of transdermal cannabinoid medications. Applying a transdermal patch several hours before chemotherapy, and wearing it for several days, would be a convenient means for treating associated nausea and vomiting. Also, wearing a patch for a week to stimulate appetite could be a good alternative to twice a day oral dosing of dronabinol.
Human Cannabinoid Pharmacokinetics Marilyn A. Huestis Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, 5500 Nathan Shock Drive, Baltimore, MD 21146, USA
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689518/pdf/nihms-118643.pdf
Sublingual Consumption
Under the tongue, there is a vein called the sublingual gland. When a substance is administered to the sublingual gland, it gets absorbed directly into the bloodstream, which is referred to as sublingual consumption or sublingual administration. Common sublingual consumption methods include CBD tinctures, CBD lozenges and CBD sprays. Because sublingual consumption is more direct, it impacts the body quicker than oral consumption and maintains higher availability, only being degraded from enzymes in the mouths saliva. Because there are a few different factors that will impact the CBD bioavailability of sublingual consumption (most involving the quality of CBD), reported rates range from 12%-35%, which is still significantly higher than oral consumption
Vaporized Consumption
Vaporized consumption involves inhaling CBD directly into the lungs, typically through a vape pen or vaporizer device.
By directly entering the lungs, the CBD can then quickly and and directly enter the bloodstream, with decreased breakdown rates and higher bioavailability.
With numerous medical studies reporting bioavailability rates between 34–46%, and some even reporting up to 56%, vaporizing CBD is by far one of the most effective methods to take CBD, and our recommended method.
By understanding how CBD bioavailability works, it not only helps you increase the effectiveness of the CBD you’re taking, it saves you from overspending on methods with low bioavailability.
Imagine you had the choice to purchase a 500mg CBD edible for $50 or a 500mg CBD e-liquid for the same price. Here’s how the cost would breakdown:
Inhalers
Inhalers featuring 1100mg micellized full spectrum hemp oil with over 200 doses per unit. These inhalers are unique blends composed of particular plant extracts paired with specific products, that when combined, enhance their anti-inflammatory, anti-spasmodic, anti-nausea, or anti-anxietal properties.
In conclusion:
Now that you know that the way that CBD is absorbed varies depends on the administration method, you may decide that one method is more ideal than another depending on your needs. However, selecting the method with which you feel most comfortable is important as you’ll more likely be able to be consistent with your servings.
We choose co2 extracted processing as it is highly concentrated, while keeping all of the main molecular components in tact with a high purity level
We choose full spectrum over isolate and nano processes because of the product stability, shelf life, taste, and the entourage effect.
We are currently formulating our sublingual, gummy bear, and vape cartridge lines in order to offer higher bioavailability to our customers.
We hope this helps
(512) 596-2447
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